Antigen presentation by mouse monocyte-derived cells: Re-evaluating the concept of monocyte-derived dendritic cells

Antigen presentation is a key feature of classical dendritic cells (cDCs). Numerous studies have also reported in mouse that, upon inflammation, monocytes enter tissues and differentiate into monocyte-derived DCs (mo-DC) that the ability to present antigens T cells. However, population inflammatory cDCs sharing phenotypic features with mo-DC has been recently described, challenging existence vivo-generated mo-DC. Here we review describing light these findings, evaluate vivo evidence for antigen-presenting We examine strategies used demonstrate monocytic origin Finally, propose play complementary role cDCs, by presenting effector locally tissues.